The continuing viability of the free‐radical theory of ageing has been questioned following apparently incompatible recent results. We show by modelling positional effects of the generation and primary targets of reactive oxygen species that many of the apparently negative results are likely to be misleading. We conclude that there is instead a need to look more closely at the mechanisms by which free radicals contribute to age‐related dysfunction in living systems. There also needs to be deeper understanding of the dynamics (...) of accumulation and removal of the various kinds of molecular damage, in particular mtDNA mutations. Finally, the expectation that free‐radical damage on its own might cause ageing needs to be relinquished in favour of the recognition that the free‐radical theory is just one of the multiple mechanisms driving the ageing process. (shrink)

Human life expectancy has increased dramatically through improvements in public health, housing, nutrition and general living standards. Lifespan is now limited chiefly by intrinsic senescence and its associated frailty and diseases. Understanding the biological basis of the ageing process is a major scientific challenge that will require integration of molecular, cellular, genetic and physiological approaches. This article reviews progress that has been made to date, particularly with regard to the genetic contribution to senescence and longevity, and assesses the scale of (...) the task that remains. (shrink)

A recent report by Tyner et al.1 suggests that p53 is bad for longevity. Heterozygotic mice carrying a p53 mutation that apparently enhances the stability of the wild‐type protein showed shorter lifespans and faster ageing while also developing fewer tumours. This fits with the idea that cellular ageing is the price paid for better protection against unlimited proliferation of cancer cells. But other work shows that there is a strong positive association between DNA repair‐mediated protection against cancer and ageing. So (...) what are we to make of the new data with regard to overall understanding of the mechanisms of ageing? BioEssays 24:577–579, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

The prelims comprise: Introduction Genetic Architecture of the Life Span Genetics of Longevity Genetics and the Future of Old Age Conclusion.

Mitochondrial dysfunction has long been considered a key mechanism in the ageing process but surprisingly little attention has been paid to the impact of mitochondrial number or density within cells. Recent reports suggest a positive association between mitochondrial density, energy homeostasis and longevity. However, mitochondrial number also determines the number of sites generating reactive oxygen species (ROS) and we suggest that the links between mitochondrial density and ageing are more complex, potentially acting in both directions. The idea that increased density, (...) especially when combined with mitochondrial dysfunction, might accelerate ageing is supported by a negative correlation between mitochondrial density and maximum longevity in an interspecies comparison in mammals, and by evidence for an intimate interconnection between cellular ROS levels, mitochondrial density and cellular ageing. Recent data suggest that retrograde response, which activates mitochondrial biogenesis, accompanies cellular ageing processes. We hypothesise that increased mitochondrial biogenesis, and possibly also impaired degradation and segregation of mitochondria, if occurring as adaptation to pre‐existing mitochondrial dysfunction, might aggravate ROS production and thus actively contribute to ageing. BioEssays 29:908–917, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

This book is not a list or an overview of various theories of ethics. Nor is it a didactic manual for specific teaching units on moral education aimed at some group based on age or a particular theme (although some educational frameworks will be proposed). As the title suggests, the book intends to seek the starting points or foundations without which no moral education would be possible. The goal is to formulate and tackle the key questions that precede all moral (...) education. What makes ""good vs. evil"" language possible and meaningful? Can virtue be taught and learned? What makes our actions good? What is the condition of human nature? Are we naturally good, or evil? What constitutes an educator's right to morally influence anyone else (not just a child)? What is the goal of moral education? What does a morally educated person look like? And how can we ensure the coveted moral result? Or--in the words of Jan Amos Comenius, the ""teacher of nations""--how to educate a person to not only know what is good, but also to want what is good, and to do what is good ""even when no one is looking?"" ""I wish I would have had Jan Habl's concise, passionate, and eminently readable book available as a text for my ethics courses during my thirty-six years of teaching at colleges and universities in Canada. Habl not only raises the alarm about a moral crisis in Western societies today, but also provides a careful treatment of some oft-neglected presuppositions of moral education. The concluding chapter introduces us to Jan Amos Comenius, a seventeenth century Czech philosopher, theologian, and pedagogue, from whom we have much to learn about a better approach to moral education."" --Elmer Thiessen, Emmanuel Bible College ""With a sound and broad grasp of ethical (moral) theorists, Jan Habl incisively critiques the fallacies of popular theories, rendering them ineffectual if not dangerous. Then, drawing on Czech educator/philosopher Comenious, he persuasively advances a theistic proposal for nurturing moral persons and communities. Immensely timely, never more needed, a rich, compelling read for our contemporary societies if we wish for a civil and peaceful existence for ourselves and future generations. Highly recommended."" --Duane H. Elmer, Trinity International University ""You have in your hands a text by someone I take to be one of the very serious young moral philosophers of our time. The profundity of his analysis of the need for moral education reminds me of the style of analysis of one of the great moral philosophers of the final decades of the twentieth century, Alasdair MacIntyre."" --Thomas K. Johnson, World Evangelical Alliance Jan Habl is a professor of pedagogy at universities in Hradec Kralove and Usti nad Labem (Czech Republic). He has taught systematic theology and ethics at the Evangelical Theological Seminary in Prague. He has authored a number of books and studies in the areas of philosophy of education, ethics, and pedagogy, including On Being Human(e) (2016); Teaching and Learning Through Story, Comenius' Labyrinth and the Educational Potential of Narrative Allegory (2014). (shrink)

Fuzzy logics are in most cases based on an ad-hoc decision about the interpretation of the conjunction. If they are useful or not can typically be found out only by testing them with example data. Why we should use a specific fuzzy logic can in general not be made plausible. Since the difficulties arise from the use of additional, unmotivated structure with which the set of truth values is endowed, the only way to base fuzzy logics on firm ground is (...) the development of alternative semantics to all of whose components we can associate a meaning. In this paper, we present one possible approach to justify ex post Łukasiewicz Logic as well as Basic Logic. The notion of ambiguity is central. Our framework consists of a Boolean or a Heyting algebra, respectively, endowed with an equivalence relation expressing ambiguity. The quotient set bears naturally the structure of an MV- or a BL-algebra, respectively, and thus can be used to interpret propositions of the mentioned logics. (shrink)

ArgumentCreated in 1884, the U.S. Bureau of Labor Statistics has been the major federal source for data in the United States on labor-related topics such as prices, unemployment, compensation, productivity, and family expenditures. This essay traces the development and transformation of formal and informal consulting relationships between the BLS and external groups over the twentieth century. Though such a history cannot, of course, provide a comprehensive analysis of how political values have shaped the construction of labor statistics during this period, (...) I argue that it can nevertheless provide important insights into the political context for the construction of knowledge about American workers and their living and working conditions. (shrink)

Since the onset of the latest United States (U.S.) recession (beginning in December 2007), the U.S. economy has been posting high unemployment levels consistently exceeding 8 percent. Of specific interest, the U.S. Department of Labor, Bureau of Labor Statistics (BLS), reports on a specific subset of the U.S. unemployed: the long‐term unemployed, defined as those who are unemployed for 27 weeks and over. Since December 2009, the share of the long‐term unemployed of the total U.S. unemployed has exceeded 40 percent (...) (through April 2012), the highest level since 1948 when data was first collected. A phenomenon of this recession is an alleged public bias by American private sector employers against hiring the long‐term unemployed, or even simply those unemployed. While the authors support the removal of discrimination against the unemployed in job advertisements, they cannot support the larger notion of including those who are unemployed as a protected class of employees. Becoming or being unemployed is a state that one can change, and based on the lack of research on how widespread this discrimination is (beyond anecdotal stories or limited research surveys), they believe that extending protection under equal employment opportunity legislation would be overreaching and inappropriate at this time. (shrink)

Logics designed to deal with vague statements typically allow algebraic semantics such that propositions are interpreted by elements of residuated lattices. The structure of these algebras is in general still unknown, and in the cases that a detailed description is available, to understand its significance for logics can be difficult. So the question seems interesting under which circumstances residuated lattices arise from simpler algebras in some natural way. A possible construction is described in this paper.Namely, we consider pairs consisting of (...) a Brouwerian algebra and an equivalence relation. The latter is assumed to be in a certain sense compatible with the partial order, with the formation of differences, and with the formation of suprema of pseudoorthogonal elements; we then call it an s-equivalence relation. We consider operations which, under a suitable additional assumption, naturally arise on the quotient set. The result is that the quotient set bears the structure of a residuated lattice. Further postulates lead to dual BL-algebras. In the case that we begin with Boolean algebras instead, we arrive at dual MV-algebras. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Alzheimer's Disease, Mild Cognitive Impairment, and the Biology of Intrinsic AgingThomas B. L. Kirkwood (bio)Keywordsaging, Alzheimer’s disease, genetic mutation, mild cognitive impairment, telomereThe article by Gaines and Whitehouse (2006) raises key questions about the uncertain relationship between (i) the intrinsic, "normal" aging process, and (ii) the clinicopathologic states represented by the labels of Alzheimer's disease (AD) and mild cognitive impairment (MCI). This short commentary offers a perspective on (...) this debate that is drawn from a consideration of underlying biological mechanisms.Because age is unquestionably the greatest single risk factor associated with AD and MCI, I begin by asking what we know about the intrinsic processes of aging. The central feature of current understanding of intrinsic aging is that it consists of the gradual, lifelong accumulation of a wide variety of molecular and cellular faults that begins very early in life and eventually leads to overt functional impairments resulting in age-related frailty, disability, and disease (Kirkwood 2005). This is an essentially bottom-up process. A strong consensus has emerged in recent years that there is no active program for aging and that there are no genetic factors that have evolved specifically to cause aging or age-related diseases. Unquestionably, there are genes that influence susceptibility to disease and even length of life, but these genes are genes for maintenance and repair functions, not for aging. It is the limitation in the past evolutionary pressure to invest in greater longevity than was required, within an environment where life was usually truncated by hazards such as starvation, injury, or infection, that means that our maintenance systems—good as they are—are insufficient to keep us going indefinitely. Added to this is the idea that there are probably also genes that program processes that are good for the young organism, but which may in later life have harmful effects. Processes like inflammation and apoptosis, which are seen to occur extensively in aged tissues, including brain, surely evolved to help cope with infection and cellular damage arising earlier in life. That they are called into play in aged tissues is a direct, but secondary, consequence of accumulated damage.With this general framework to understand the intrinsic biology of aging, let us now ask what we might expect a priori for the aging of an organ such [End Page 79] as the brain. Although we cannot pretend complete ignorance of how the brain actually does age, our enquiry can be based entirely on data from other organ systems, so we can develop our predictions about brain aging without prejudice.Aging begins very early during human development, faults accumulating from the first stages of embryonic development. Each time a cell divides, each of the daughter cells is likely to acquire a few new mutations. We know this from the estimates for the error rate in DNA replication and the size of the human genome. It is confirmed by direct evidence that at individual gene loci where mutations have been measured, mutation frequency increases with age (Morley 1998; Vijg 2000). In addition to replication errors, DNA is damaged on a daily basis to a very considerable degree by agents such as reactive oxygen species (free radicals), which are formed as byproducts of normal cellular metabolism. Although most of this damage is corrected by repair, the repair mechanisms themselves are not error free and additional mutations accumulate through this route. If a mutation is lethal to the cell, the cell dies and thus the mutation is eliminated. However, the majority of mutations are nonlethal, either because the mutation is recessive and the cell carries an intact gene copy on the other chromosome, because the gene is not currently required, or because the mutation produces only a delayed deleterious effect. Examples of genes that produce delayed deleterious effects include the genes responsible for familial AD. It is interesting to reflect that on statistical grounds alone, it is almost certain that each of us carries a randomly determined fraction of cells in our brains that bear amyloid precursor protein or presenilin mutations associated with AD. We also carry a heterogeneous array of random mutations that compromise essential cell maintenance functions. How many such... (shrink)

This article sheds new light on the interesting but little-studied figure of Thomas Scott of Canterbury (1566–1635). In presenting Scott's ideas I will modify the interpretation laid out by Peter Clark whose groundbreaking study, ‘Thomas Scott and the Growth of Urban Opposition to the Early Stuart Regime’, is still the only secondary source that pays detailed attention to Scott and his thought, especially his religious opinions. The necessity to revisit Clark's interpretation of Scott's place within the political and (...) doctrinal debates of early Stuart England stems from the conviction that his political work and his ideological stances deserve more subtle attention. Most importantly, they were part of the emerging reaction against the policies of the first two Stuart Kings which can be labelled ‘country patriotism’. Finally, the elucidation of Scott's writings will provide a novel insight into an early configuration of English national identity. ☆ Earlier versions of this article were presented at the seminar ‘British History in the 17th Century’ held at the Institute of Historical Research (London) and at the ‘Modern History Seminar’ held at the History Department of the University of Birmingham. I wish to thank the audiences on both occasions for their questions and comments, especially Justin Champion, Richard Cust, John Miller. I would also like to thank Jonathan Scott, Johann P. Sommerville and Richard Whatmore for reading the text. This article is based on archival research pursued at the Kentish Archive Office, Maidstone (KAO), Canterbury Cathedral Library (CCL), Bodleain Library, Oxford (BLO) and British Library, London (BL). The manuscripts referred to in the text are listed as KAO U951/z/9, U951/z/10, U951/z16, U951/z17 (Knatchbull Papers); CCL Urry Mss 66 (‘Thomas Scott's Papers on the Elections to the Parliament of 1626’, 1a–141a); BLO Ballard Ms 61; BL Harley 7018, Additional MSS 62135, n. 31. The majority of the material consists of Scott's diary and of a series of mostly unfoliated papers in Scott's own hand. Some portions of the diary are in secretarial hand, whilst others are reproduced in Proceedings in Parliament 1628, ed. R.C. Johnson et al., 6 vols. (New Haven and London, 1977–1983), VI, Appendixes and Indexes, 126–37, 218–43 (hereafter PP 1628; where there are passages in both manuscript and printed form I refer to the latter). Amongst the miscellanous Scott manuscripts two are in Bodleian Library, Rawlinson Ms A 346, 224a–34b and 285a–97b. These are transcribed and published in Dorothea Scott, otherwise Gotherson and Hogben, of Egerton House, Kent, 1611–1680, A New and Enlarged Edition by G.D. Scull (Oxford, 1883) (hereafter Dorothea Scott). (shrink)

Conscience and Conscientious Objection of Health Care Professionals Refocusing the Issue Content Type Journal Article Pages 351-364 DOI 10.1007/s10730-009-9113-x Authors Natasha T. Morton, The University of Western Ontario Ontario Canada N6A 5B9 Kenneth W. Kirkwood, Arthur and Sonia Labatt Health Sciences Building London Ontario Canada N6A 5B9 Journal HEC Forum Online ISSN 1572-8498 Print ISSN 0956-2737 Journal Volume Volume 21 Journal Issue Volume 21, Number 4.

There is a difference between that which is and that which is to be. Anthropologically: there is a way I am, and the way I am to be, or not to be. How are we to explain this? This book presents the argument that human nature is both complex and complicated in at least two specific ways--ontologically and ethically. In our being we are indisputably good, dignified, worthy, important, or even noble. But in our morality we are ambivalent--capable of both (...) good and evil, the humane and the inhumane. In his paramount work Jan Amos Comenius expresses the goal of his lifelong endeavor: "to help keep man from falling into a non-man" (Pampaedia). If human beings are to become what they ought to be, they need to be educated towards humanity, says Comenius. But the fundamental question is, what is a human being? And what ought one to be? "Salt ought to be salty. A river ought to be clear. A knife ought to be sharp. But what ought a person to be?" What is the essence of our humanity? And how can that be cultivated or educated? This book presents Comenius's answers to these questions. (shrink)

The aim of this book is to explore the possibilities and limits of Comenius's greatest and most important work, General Consultation Concerning Restoration of Human Affairs. The humanity of people is not quite right, but not quite lost--that is the foundational anthropological assumption of the Consultation. How does Comenius understand humanity? What are human affairs? What's wrong with them? And the most important question: Can they be somehow corrected, improved, or restored?

When making decisions, humans can observe many kinds of information about others' activities, but their effects on performance are not well understood. We investigated social learning strategies using a simple problem-solving task in which participants search a complex space, and each can view and imitate others' solutions. Results showed that participants combined multiple sources of information to guide learning, including payoffs of peers' solutions, popularity of solution elements among peers, similarity of peers' solutions to their own, and relative payoffs from (...) individual exploration. Furthermore, performance was positively associated with imitation rates at both the individual and group levels. When peers' payoffs were hidden, popularity and similarity biases reversed, participants searched more broadly and randomly, and both quality and equity of exploration suffered. We conclude that when peers' solutions can be effectively compared, imitation does not simply permit scrounging, but it can also facilitate propagation of good solutions for further cumulative exploration. (shrink)

INTRODUCTION Although the writings of Thomas Reid are very fertile and interesting, his life is biographically barren in comparison to such seventeenth - and ...

Using a case of intended but failed doping, the author seeks to answer the question of if an agent cheated when they intended to but failed in the case of doping due to inert, counterfeit drugs. The examination looks at the case using the concept of cheating and concludes by dividing the results of cheating into primary and secondary effects.

THE NATURE OF ART is a collection of 29 seminal, historically-organized readings that are focused on a basic philosophical question: What is Art? Including writings from the Western tradition'both Continental and Analytic traditions'as well as non-Western, minority, and feminist writings, this volume provides students with a rich set of resources to explore this matter both broadly and deeply. Introductions to each reading situate the selection amidst each respective thinker's body of work and the greater philosophical context in which the remarks (...) arose. Reading questions accompany each selection, drawing students' attention to key points to be encountered. Hailed by reviewers and adopters for its clarity and rigor, Wartenberg's THE NATURE OF ART offers a lively and engaging introduction to the philosophy of art. (shrink)

The newly updated Right and Wrong 2nd Edition is an accessible introduction to the major traditions in western philosophical ethics, written in a lively and engaging style. It is designed for entry-level ethics courses and includes real-life ethical scenarios chosen to appeal directly to students. Greatly expanded and improved, this successful text introduces students to the major ethical traditions, and provides a simple methodology for resolving ethical dilemmas Treats teleological and deontological approaches to ethics as the two most important traditions, (...) but now includes chapters on virtue ethics and the ethics of care The very accessible writing style speaks directly to students’ own experience Draws examples from three types of real-life ethical scenarios submitted by students: academic dishonesty, partying, and personal relationships Provides a concise treatment of this notoriously complex subject, perfect for entry-level ethics and applied ethics courses. (shrink)

This chapter contains section titled: Personhood: A Start Are Dolphins Persons? Language and the Hand Personhood Redefined Conclusion: What Kind of Beings Are Dolphins?

David Ekdahl (2023), in a constructive and thoughtful commentary, outlines both points of agreement with and suggestions for further research arising from our paper ‘Crossing the Fictional Line: Moral Graveness, the Gamer’s Dilemma, and the Paradox of Fictionally Going Too Far’ (Montefiore & Formosa, 2023).

According to a widely held view, a Kantian intuition functions like a singular term. I argue that this view is false. Its apparent plausibility, both textual and philosophical, rests on attributing to Kant a Fregean conception of judgment. I show that Kant does not hold a Fregean conception of judgment and argue that, as a consequence, intuition cannot be understood on analogy with singular terms.

In this book Thomas Wren uncovers and assesses the largely hidden philosophical assumptions about human motivation that have shaped contemporary psychological ...

This interdisciplinary volume questions one of the most fundamental tenets of social theory by focusing on detachment, an important but neglected aspect of social life. Going against the grain of recent theoretical celebrations of engagement, this book challenges us to re-think the relational basis of social theory. In so, doing it brings to light the productive aspects of disconnection, distance and detachment. Rather than treating detachment simply as the moral inversion of compassion and engagement, the volume brings together empirical studies (...) and theoretical comments by leading anthropologists, sociologists and science studies scholars. Taken together, these illustrate the range of contexts within which distance and disconnection can offer meaningful frameworks for action. Positioned at the cutting edge of social theory, this landmark volume will be of great interest to students and academics across the social sciences and humanities. (shrink)

Optical media were instrumental in transforming the conception of facts, objectivity, and the »real.« This paper considers their role in structuring understandings of counterfactuals and states that could not be real. By returning to Ernst Mach’s photographic ballistics experiments, writing on thought experiments (a term he coined), and his dispute with Max Planck about the nature of the Weltbild, the article shows that, despite his legacy as a positivist, Mach’s epistemology of mechanical images opened a legitimate space of indeterminacy, contingency, (...) and counterfactuality. (shrink)

A problem in the text of Pindar, the interpretation of λαρετον, O. 2. 87, seems to be vanishing, swept away by a remarkable consensus of recent criticism, a consensus the more remarkable in that it accepts a false solution to a genuine difficulty. This article has two purposes, the first and more important of which is to argue that the currently prevailing answer is manifestly wrong, the second to offer evidence in support of a different approach. Simply read γαρυτων, recent (...) critics maintain, and all problems disappear. Since -ο- and -ω- were not yet distinguished in the orthography of Pindar's day, γαρυτων is as correct as the unanimous γαρύτον of the MSS, testimonia, and scholia. By this simple change, the argument proceeds, the troublesome dual of the MSS is purged and with it the ‘historicist hare’, as one critic has recently called it, which less enlightened Pindarists chased for so long. If there is no dual, there is no need to speculate as to the identity of the ‘pair’ likened to κρακς and contrasted with the ‘divine bird of Zeus’, the man who is wise φυ. We need no longer suppose that the μαθντς are Simonides and Bacchylides – the traditional answer – or any other specific rivals. Unfortunately for this view, there is no evidence to justify taking γαρυτων as a plural, which is of course precisely what critics have been doing. It is – if anything – a third dual imperative , and every bit as much a dual as the γαρύτον of the MSS. Mr Stoneman is not alone in his ready dismissal of the ‘historicist hare’. Here is the view of Professor Lloyd-Jones: ‘… the lightest possible alteration converts the dual to a plural imperative, so that the number two vanishes’. A year before, Professor C. A. P. Ruck had chided the scholiasts for ‘reading out of Pindar's ΓΑΡΥΕΤΟΝ the dual…rather than the plural’. Bowra had declared that γαρυτων ‘would be the plural of the imperative’. The belief is widespread and persistent; those who wish a full conspectus of earlier views on the matter may consult the massive compilation made by Dr J. van Leeuwen in 1964. Not all critics and editors have endorsed the change from the traditional reading. While it has been in the successive Teubner editions since Schröder adopted it in 1900, neither Turyn nor Bowra accepted it. But among those who have argued for γαρυτων, only one has expressed any doubt that it is a plural, and that one is Theodor Bergk, who first proposed it. Indeed Bergk expressed no doubt about its being a dual. (shrink)

The reaction to Darwin's Origin of Species varied in many countries according to the roles played by national scientific institutions and traditions and the attitudes of religious and political groups. The contributors to this volume, including M. J. S. Hodge, David Hull, and Roberto Moreno, gathered in 1972 at an international conference on the comparative reception of Darwinism. Their essays look at early pro- and anti-Darwinism arguments, and three additional comparative essays and appendices add a larger perspective. For this paperback (...) edition, Thomas F. Glick has added a new preface commenting on recent research. (shrink)

Big Ideas for Little Kids includes everything a teacher, a parent, or a college student needs to teach philosophy to elementary school children from picture books. Written in a clear and accessible style, the book explains why it is important to allow young children access to philosophy during primary-school education. Wartenberg also gives advice on how to construct a "learner-centered" classroom, in which children discuss philosophical issues with one another as they respond to open-ended questions by saying whether they agree (...) or disagree with what others have said. (shrink)